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Glycerin Extraction

Kosher vegetable glycerin is an effective method for extracting cannabis concentrates directly from the plant material and produces a tasty medication that is easily ingested directly orally, or mixed with drinks and food.

Glycerin is a heavy, syrupy clear liquid sugar alcohol that has approximately 60% of the sweetness of sucrose, and about the same food value.

It is however not actually a true sugar and is often used as a sugar substitute, as diabetics are often able to use it without experienced the blood sugar rollercoaster they suffer with sucrose or other sugars.

Glycerin makes an extremely tasty and provocative cannabis tincture, that when made using cold extraction methods, is reminiscent of wild honey, as it preserves all the individual flavors, so that they dart off in all directions simultaneously.

Hot glycerin extraction also makes a tasty tincture, with the flavor more resembling a fine soup, where the individual flavors are married into one overall flavor. While not as whimsical and provocative as a cold extraction, it can be prepared start to finish in a couple days, where cold extractions take a minimum of 60 days and are commonly soaked for 120 days or longer.

Many of the provocative flavors and odors from cannabis are aromatic terpenes, and the reason that they are aromatic in the first place, is that they give off molecules at room temperature.

Heating speeds up the rate that the accompanying terpenoids and other aromatics are vaporized off, so many are collateral damage in a hot extraction and are lost.

The glycerin molecule is actually only a three carbon molecule chain, with three hydroxyl groups (OH) attached, and as hydroxyl groups are hydrophilic, glycerin is hygroscopic (absorbs water) and dissolves readily (miscible) in water.

It has a flash point of approximately 177C (351F), and a boiling point of 290 °C (554°F).

It is relatively non toxic. The MSDS tells us that the LD50 Oral rat dosage is 12,600 milligrams per kilogram of body weight, which is approximately 5.7 grams per pound of body weight, or 36 ounces for a 180 pound male.

By comparison, acute oral toxicity (LD50) Oral Rat for sucrose sugar is 29700 mg/kg and about 7060 mg/kg for ethyl (grain) alcohol.

At saturation, Glycerin only hold as 33% as much cannabis oil as the same volume of ethyl (grain) alcohol, so about three times more is required per dose.

To reach maximum saturation however, requires processing more than one batch of fresh material through the glycerin, because as the saturation level increases, the glycerin becomes less aggressive as a solvent and the partially dissolved cannabis boundary layer interface with the solvent is also no longer at full strength and as reactive.

To keep the reaction from slowing to a snails pace, or even stopping, some method must be used to keep removing this stagnant layer and refreshing the boundary between the solvent and resin.

In addition, heat dramatically affects resin dissolution rates. The hotter it is, the faster it works, up to the point of overheating.

As glycerin is usually used as an oral med, we also need to consider decarboxylating the cannabinoids so that they are orally active.

If not in excess, some water solubles add to the flavor of a glycerin tincture, and taking all of the water out of the material before processing it, makes it frangible and prone to breaking into small fragments that may be hard to remove.

Let's look at how these four variables can be manipulated to produce delicious and effective glycerin tinctures.

Drying and decarboxylation:

Plant material is typically dried to around 10/15% water content by weight for smoking and vaporizing purposes, which is low enough to make some delicious glycerin, but for those who prefer less water solubles in their glycerin tincture or wish to decarboxylate the material before extracting, you may add a drying and/or decarboxylation step.

To simply remove most of the remaining moisture, I place the plant material on a cookie sheet in a 200F oven and turn it, until it is frangible when I roll it between my finger and thumb.

At that point it is ready for extraction, but if you also wish to decarboxylate the plant material before making your tincture, you can then crank up the oven to 250F and after it stabilizes at the higher temperature, replace the plant material in the oven and hold it at temperature for approximately 30 minutes.

That will add a roasted flavor to the tincture and many of the turpenoids will be lost, but it will decarboxylate approximately 70% of the existing carboxylic acids into their non acid orally active form.

An alternative to decarboxylating the material ahead of time, is to do it after the extraction is complete and the plant material has been filtered out. That eliminates the roasted flavor and preserves more of the turpennoids.

Using Temperature:

Elevating the temperature of the glycerin increases the rate of dissolution of the resins, especially if you raise the temperature high enough for the resins to be molten. THC, CBD and CBN are all molten at just under 180F, so we operate at that temperature.

The advantage of using as low a temperature as possible, is that fewer aromatic terpenoids are boiled off at that low a temperature, and it decarboxylates more slowly, so that the process doesn't pass the peak of the decarboxylation curve and start down the other side toward low THC and high CBN. As previously noted, we can finish the decarboxylation later.

Keeping the boundary layer removed:

The boundary layer is the layer of partially reacted resin and dilute solvent that forms on the surface of the resin after the initial aggressive dissolution by the solvent. The solvent at that point is dilute, as is the resin concentration, so that the reaction slows or grinds to a halt.

To keep the reaction operating at a reasonable rate, we need to periodically or continuously remove that boundary layer, and there are four methods that I will present here.

The first is to stir. Simply stir gently and thoroughly with a wooden spoon.

The second is to shake. Simply shake a jar of glycerin and plant material by hand regularly. A paint shaker would also work for this application.

The third is to tumble. Placing the jar of glycerin and plant material in a rock or photo film tumbler will keep the boundaries fresh. It is an effective and gentle way to speed up the process.

The forth is vibration. Placing jar of glycerin and plant material in a vibratory cartridge case cleaner, or other form of vibration, creates more shear energy that tumbling and will dissolve the material the fastest of any method we have tried thus far.

Material selection and preparation for hot or cold processing:

While glycerin tincture can be made from anything from prime bud to stems, it is tastiest done from prime bud and least tasty with the stems. I usually make glycerin tincture out of the sweet trim removed from the buds during manicuring and popcorn buds.

It is not necessary to grind up the material, only to break it up any buds so that the material is loose enough for the glycerin to reach all the surfaces. Excessive pulverization of the material will result in color and particulate pickup that is difficult to remove. If you leave some surfaces blinded however, the resins on those surfaces won't be removed either.

Extracting using the cold process:

The cold process is the easiest and tastiest way to make glycerin tincture. We extract using the cold process, simply by soaking the plant material in glycerin at ambient temperatures and agitating it for sixty days or more. Sixty days is about the least amount of time for a cold extraction, and typically they are run 90 to over 120 days. I have one experiment with more than 365 days of soak time.

After the extended soak and agitation, the glycerin is poured off and pressed out of the plant material to yield quality and tasty tinctures. It can also be used with fresh material for another cycle, so as to build up more potency.

There are a number of ways to press out the glycerin from the plant material, and it applies to both cold and hot extraction, so I will cover that in a separate discussion at the end of extraction methods.

The way that we make cold process glycerin tincture, is to load a canning jar 2/3'ds full of plant material, lightly compacted and then cover with glycerin while stirring with a wooden spoon, until every surface is well coated and mixture is homogenous, and then add another inch of glycerin on top.

We place the jars in a cool dark place or cover to exclude light. We sometimes wrap jars with aluminum foil to exclude light.

Every day for the soak period days, we periodically agitate the jars, using one of the above methods and at the end I filter out the plant material for a a light golden to dark amber glycerin tincture, that is tasty and of high quality.

Because the aromatic terpenoids are preserved, it will have many flavors present, interacting and darting off in all directions simultaneously.

You can more easily filter the mixture if you warm it up to 150F or so before filtering.

Potency and gleaning:

As previously noted, to reach maximum saturation, requires processing more than one batch of fresh material through the glycerin, because as the saturation level increases, the glycerin becomes less aggressive as a solvent and the remaining partially dissolved cannabis is also no longer at full strength and as reactive.

In point of fact, the fresh pressed material from the above first cycle will still contain significant cannabinoids, which takes two to three cycles to get it all.

What we do is put the fresh pressed plant material back in the jar and refill with fresh glycerin and add fresh material to the freshly pressed glycerin for another cycle, if I desire more strength.

The fresh glycerin will do the best job of scavenging the remaining cannabinoids, and then can be used again with fresh material to further build up its potency. It is by this cascading technique, that we can leave little behind and yet still maintain quality and potency.

I should note that the most potent glycerin tincture is not necessarily the most tasty, and one cycle produces effective meds, so most of the time we do not bother to bump up the potency with cold tincture.

Hot glycerin extraction:

We prepare plant material and extract cannabis by the hot glycerin extraction process in much the same way as we do by the cold process, though we stir it instead of shaking, tumbling, or vibrating it.

We also use a thermal cycling process and stir regularly, rather than an extended cook as many processes call for. The expansion and contraction of the thermal cycling help break up the resins so that they dissolve more readily.

As with cold tincture, we load a canning jar 2/3'ds full of plant material, lightly compacted and then cover with glycerin while stirring with a wooden spoon, until every surface is well coated and mixture is homogenous, and then add another inch of glycerin on top.

We then set that jar in an electric fondue pot full of hot Canola oil at 200F, and stir it regularly with a wooden spoon until the mixture reaches 180F, and then we adjust the pot temperature controls to maintain 180F.

We stir the mixture regularly with a wooden spoon, for another thirty minutes, and then take it out of the hot oil and allow it to cool to ambient temperature.

For what it's worth, we use a wooden spoon, because a light tink with a metal spoon against a hot glass jar while stirring, can break it and dump the whole mixture into the hot oil.

After the mixture has cooled to room temperature, we again place into 200F oil and bring it back up to 180F while stirring regularly. When it reaches 180F, after a through stir, we take it out of the hot oil and let it cool to ambient temperature again.

We repeat the last step about five more times and after the last cook and stir; we filter out the plant material while the mixture is still hot.

Filtering glycerin tincture:

Vegetable glycerin is thick and syrupy, so it doesn't filter quickly or easily without mechanical help. The simplest way to filter it is to heat it up so that it isn't so viscous, and pour it into a jelly bag, which you wring out by hand. That works, but leaves a lot of glycerin behind and you are limited to temperatures that you can handle with your hands.

A French coffee press, a potato ricer, or a jelly press can also work, and you can buy tincture presses used by the botanical extraction industry.

We made my own press, using a hydraulic bottle jack inside a scrap metal frame, which presses a filter bag between two stainless dog dishes, at a force of 12,000 psi, and catches the glycerin in a third stainless dog dish.

It presses the plant material into a hard little puck, that we have to break up to reprocess.

Flavoring glycerin tincture:

A well made glycerin tincture is a taste delight in its own right, but for those of ya'll who just like to play, here is how we've flavored glycerin that I had already infused with cannabis oil.

We started by adding equal parts of Bing Cherry and Blueberry raisins in a blender with enough 190 proof grain alcohol to make a soupy paste when macerated by the blender.

We tossed in half as much Japanese Gari and a dash of Almond extract, added another half a cup of 190 proof, and let it blend well.

When pureed, we poured it into a stainless mixing cup and placed it in a 180F hot oil bath. We cooked and stirred it until all the alcohol was gone, and then removed it to cool.

We then put about two tablespoons of that concentrate into each 1/2 pint of infused glycerin to be flavored and place it in the 180F oil to cook for thirty minutes while stirring regularly.

At that point we remove it from the oil, filter out the concentrate using a filter bag and the glycerin press. The glycerin is delightfully flavored, and the chef gets to eat the concentrate from the filter bag! Ahwooooooooooooooooooooooooooooooo!!!!!!!!!! Hee, hee, hee....................

Above

Hot soak for one week; Hot cycle 7 times;Cold vibrate; Hot cycle and vibrate Cold Vibrate                                                                               Density samples Second pressing of material                                                160F cycled 7 times Cold press 60 days                                                                   Hot versus cold extraction

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260 Comments

  1. Greg

    How can an ejuice that works be made then? Connoisseur concentrates makes a solution that claims .3ml to 1gram concentrates. Holy terp makes pure, same. Which would presumably make a more potent ejuice than 1:1 liquidizers. Are terps any safer to vape than pg or peg? Does that e juice work? Seems No one is looking for the answers but consumers. Also if the concentrated isn't decarbed how can an ecig decarb it? It's not 400 deg like a flower vape is it? I plan to make 1g dry ice hash, then decarboxilate it. Then add CC .3ml. If it doesn't work last try. I've used wax liquidizer 2 times. But pg peg scares me. And it only kinda worked. More like if you were already lifted it would easily keep you up. But wouldn't really Lift you up on it's own. Hope Someone figures it out.

    Reply
  2. Jason L

    Maybe try forming the "deep eutectic solvent" glyceline by mixing 1 mole of choline chloride or trimethylglycine with 2 moles of glycerol and heating/stirring for about 2 hours at about 80 C until a clear liquid is formed. It will be less viscous than glycerol and its solvent powers will be increased dramatically, like an extraction requiring less than 2 hours rather than days or months. It would be hard to recover the cannabinoids from the DES, other than by adding a lot of water, but it could be used as it, since choline chloride or trimethylglycine are non-toxic like glycerol. In fact it would probably aid in absorption. The deep eutectic solvents are similar to DMSO as solvents, polar aprotic. Adding water at 10-30% reduces polarity and makes it work better for most extractions. BTW menthol forms DES at room temperature with camphor and other substances, including various organic acids, lactic, pyruvic, lauric etc. I think a DES could be formed between menthol and THCA, making it a liquid at rt and more absorbable. Don't know if liquid THCA would be desirable or not, but should be possible at least. May have more medical benefit.

    Reply
  3. Patimah

    If I do glycerin extraction using cold maceration for a week then, I want to centrifuge it. so, what suitable temperature and rpm should I use?

    Reply
  4. How To Make Cannabis Tincture/ e-Cig Juice (Quick Vegetable Glycerin Method): Cannabasics #29 –

    […] More reading: https://skunkpharmresearch.com/glycerin-extraction/ […]

    Reply
  5. Daniel Blue

    I've had my VG?Flower mix sitting(shake twice daily) for 90days now. However,I failed to decard flower prior to mixing. Plan to sit an additional 90 days. Do I have to decarb or activate with an additional step or steps? If so do I perform a hot oil bath or what? answer is greatly appreciated. Will decard next batch prior to mixing.

    Reply
  6. How To Make Cannabis Tincture/ e-Cig Juice (Quick Vegetable Glycerin Method): Cannabasics #29 –

    […] More reading: https://skunkpharmresearch.com/glycerin-extraction/ […]

    Reply
  7. emac757

    Shelf life is definitely limited. Iv had hot extracts that knocked your head of with 10 drops. Few weeks later, not so much. 2 months later, nada. Cannabinoid degradation is a study i would love tof read one day.

    Reply
  8. Rob

    Good for baking? I had a ton and just baked up a batch with 125ml of glycerin tinc. Figured some may vape off at low temp. So again, is it a feasible option for brownies? What should I try for dosage?

    Reply
    1. Skunk Pharm Research,LLC

      You can cook with it. One problem to keep in mind with medibles is always the question of how many they are going to eat, which can change from planned if they are tasty and their will is weak. Determining dosage accurately would require analyzing it for THC content. WA state allows 10 mg THC per dose and 10 doses per package. GC

      Reply
  9. Savana

    Thank you for this wonderful article! I have a question regarding THC extraction. Is THC able to be extracted with glycerin or ethanol? I ask because I read that THC is oil-soluble so I have always wondered how people extract the THC for (let's say) fruit juice. I have never tasted alcohol and felt glycerin would contribute a thickness to the finished product. I just don't see how an average joe is extracting enough THC without an oil-soluble medium. Thanks in advance!!

    Reply
    1. Gage Ridenour

      THC is soluble in Fats and alcohols. The quote below gives you a brief description of why THC is soluble in Glycerin(because the fatty acid molecules are bound to carbon atoms in the Glycerin Molecule). Im assuming the same fatty acid molecules are found in other oils as well. For example One reason people use Coconut oil as opposed to canola oil is because of the fatty content of it. Compared to say vegetable oil which is at a liquid state at room temperature, coconut oil is a solid at room temp because of the fat content. "The carboxyl end of each fatty acid reacts with the hydroxyl group on each carbon atom of a glycerin molecule. This results in each fatty acid molecule being bound to a carbon atom in the glycerin molecule". In regards to your THC in fruit juice question--> Glycerin is water soluble. So once the THC is extracted (must be decarboxylated as well) into the fatty molecules of Glycerin, it can be directly added to anything like a juice or tea, as well as cooked with for most sweet recipes (I.E Gummies) Hope this helps brotha! Happy early 4/20, keep it hippppie!

      Reply
  10. Jay Thomas

    Great article and research! Thanks for sharing. Regarding the Hot glycerin extraction, are there any benefits of doing this on the stove with oil (vegi oil I assume) vs the crock pot (wash cloth on bottom, jar on top then half filled water) for 24 hrs shaking every hr? Also if you had to pick a setting of simmer 185F or I could use warm setting 165F which would work better? really appreciate it =)

    Reply
    1. Gage Ridenour

      The reason people use Vegetable Oil baths is because it more stable in regards to keeping temperature. The reason they say to heat to at least 180F is because this is the point at which cannabinoids become molten and are more easily/more quickly soluble. From my research I have found most people use a range of 180-220F when using the heating method for tinctures. I think the crockpot method would be fine, the only reason they use vegetable oil is solely for the stability compared to water! One plus of the stove top is that if you have a thermometer it is much more easy to keep the temperature where you want it :)

      Reply
      1. Jay Thomas

        Thanks! Any idea how long the shelf- life before it starts to degrade? Is it true after a month? Made a bunch with your method above 50%/30%/8%/12% vg/pg/distilledwater/flavoring for vaping, came out great! Not sure how long it will last storing it though ;D

        Reply
    1. Skunk Pharm Research,LLC

      No, but extracting with VG doesn't produce a very exciting vape solution due to low concentration. GW

      Reply
  11. Tom

    you said... "You can reduce the alcohol sting, by simply removing most of it. 50% concentrate in 50% 190 proof, cuts the alcohol potency in half." i use 2 ml tincture daily and cutting the burn would be such a blessing. i dont want to use heat to remove grain alcohol but i need to stay with 190 proof due to cost [cant afford three times as much just for good taste]. thank you in advance for your more detailed clarification of how to reduce alcohol sting... we all thank you.

    Reply
    1. Skunk Pharm Research,LLC

      You can naturally evaporate some of the alcohol away without heat, if you want less. 75% concentrate and 25% 190 proof is below sipping whiskey levels and about in the brandy range. Pour it in a pyrex pie plate, cover with a cloth to keep dust out, and the alcohol will leave all on its own. GW

      Reply
  12. Scott

    Ive tried it exactly as you have suggesting atleast 10x. Maybe more!!! It simply does not work. I have decarbed before and after. I have tried 180, 190 and 200+ all different runs. I have tried it all! The VG absorbs some THC but it is very very little and comes across as more of a sleep-aid than anything. (and its not even good sleep aid).... I have tried cooking in veg oil and water. Nothing. crock potting/longer runs...No dice. Same ol weak garbage. VG is just too poor of a solvent to make this happen.

    Reply
    1. Skunk Pharm Research,LLC

      Make what happen?? There are brothers and sisters who have been using glycerin tincture for more than a decade since I've been aware of it and swear by it. The question is how are you using it and what effects are you looking for??? If you are looking for pipe juice or a soaring euphoric high, you will be disappointed. The pipe juice won't be potent enough and your liver processes what you take orally and most test volunteers reported the effects as more of a feeling of relaxed well being. As far as a sleep aid, the right strain and dosage certainly could be. GW

      Reply
      1. Scott

        A friend of mine has given me gummies/gum drops on a number of occasions. They are out of the world potent! Consistent as well in the dosing....... Extremely heady and energetic. I was convinced they were made with VG. Now after a number of trials i am thinking otherwise. If you can't make VG euphorically(is that a word) potent what in the hell is the baker making these gummies with ??? *They are delicious as well.

        Reply
        1. Skunk Pharm Research,LLC

          Recipes vary, but he is most likely adding concentrate to his gummy bear mix. Here is a generic one from Wiki. The gelatin in the recipe will act as a menstruum for the concentrate. Except for the lozenges and cannapops, we backed off of making tasty medibles, because of the number of patients whom "couldn't eat just one", or two or three........, and ended up overdosing. Not life threatening, but definitely fun threatening, so except for the prestige, is a good thang to avoid. GW

          Reply
          1. Scott

            I thank you for your response.... I know I am off topic now but could you provide a link or explain how one would dissolve wax into the gelatin. Just liquify the wax under heat and mix ? or add to a lipid or ? Last question i promise :)

            Reply
          2. Steve

            For gummy bears Coconut Oil seems to work as better menstruum than gelatin. For folks who do processing, one of the biggest challenges with edibles, beverages, topicals, tinctures, etc is potency drift. We talked a client of ours, Neta Care, in Massachusetts into performing some potency analysis with their BHO extract Gummy Bears. They made two batches of gummy bears with coconut oil as the carrier. One batch was mixed with an industrial immersion mixer for one hour, the other batch was emulsified with the CAT X1000D homogenizer for one minute. Each batch made 50 gummy bears. 25 gummy bears from each batch were randomly selected and analyzed for potency deviation. The batch mixed with the industrial mixer for an hour, potency deviation of 65%. The batch emulsified with the homogenizer for one minute, potency deviation of 4%. Unfortunately, Neta Care is unwilling to share the analysis. They’re afraid if this information gets out to other processors they’ll lose the edge they have in the market. We are working with other processors who promise they'll share their potency deviation analysis. As soon as they make them available I'll post them. Steve, CAT Scientific

            Reply
        2. Nancy Not Botwin

          Because VG doesn't reduce, you can't use it for gummy bears. I use an alcohol tincture (151 or 190 proof). And reduce it down (like molasses). Obviously don't do this over an open flame. Take 2 1/2 ounces (10 envelopes of 1/4g each) unflavored gelatin Mix with 12 oz of flavored gelatin to combine. Mix 1 cup of chilled fruit juice of your choice with 1/4 of honey or agave nectar. Then add the juice & agave to gelatin and whisk. Let sit for 20 minutes. After you reduce the tincture and almost all alcohol has evaporated, add 1/2 tbsp of flavor extract and 2tbsp of honey or agave to the pan. Swirl until it looks like molasses. Add the gelatin mixture to the pan, heat over medium until gelatin has melted. Pour into molds. You can dust them with powdered sugar after you pop em out to keep from being sticky. I've been following this recipe for years that hasn't steered me wrong, firms up in about an hour. Yields about 3.5-4 c of gelatin slurry. Fills my molds to make about 350 bears. Hope this works out for you.

          Reply
  13. Dlg

    Ok that is what I thought. Thank you for your quick reply. One other question, is there anyway to tell if all of the cabinoids of have been extracted?

    Reply
    1. Skunk Pharm Research,LLC

      100% of the cannabinoids are in the trichomes. I judge when I have fully extracted material by looking for intact trichome heads under 100X magnification. When they're gone, I'm done. Don't worry about the stems, they will remain after the heads are gone. GW

      Reply
  14. Dlg

    Regarding the hot method, you mention the cold method will fail to extract all the cabinoids from the plant and you need to repeat the method to get full potential strength. Is this the same for the hot method? Or does the thermal cycle take care of this?

    Reply
  15. Cody Hopkins

    Thanks, it seems to be going well so far! I guess we won't know until the final step. I love the website, I just came across it recently. Any good links on knowledge for a first time grow? Thanks again!

    Reply
    1. Skunk Pharm Research,LLC

      You're welcome! Bon appetite! I'll let Joe and Carla answer the grow question, as it is in their areas of expertise! GW

      Reply
  16. Cody Hopkins

    I'm just trying this for the first time. I have steam heat in my house and I am storing it near my radiator. Do you expect this to be helpful, harmful or have no effect?

    Reply
    1. Skunk Pharm Research,LLC

      I think it will work and the end result will be a faster extraction. The difference between a long cold extraction and a short hot one, is flavor. Cold extractions are like wild honey, in that the flavors dart off in all directions, because of the local mix of blossoms, while hot extractions are more like the flavor of a tasty soup combining them. GW

      Reply
  17. Alv

    Pls don't bother. It simply will not work. Everyone reading this should give up on both pg and vg. It simply is not potent enough so don't waste your time. I know it's a great idea but it's only an idea. Someone should tell Ruffhouse to take down that video. It's super misleading. Utter BS even! Someone should post on the original post about this and stop wasting time of others. I'm glad I did it so I know how futile it is. Don't say I did not tell you beforehand!

    Reply
    1. Skunk Pharm Research,LLC

      I infer that you are speaking of a Vegetable Glycerine extract. For cold extract purists/aficionados, storing it a year in a cool dark place will do the trick and preserve the wild honey flavors. If you are in a hurry, stick a stainless container of the VG tincture in a 250F oil bath and watch the bubbles. Keep stirred so you can tell what is going on and when the CO2 bubble generation falls off suddenly, you are at about 70% decarboxylation and when it stops, you are at 100% decarboxylation. VG flash point is 160C/320F and the boiling point is 290C/554F, so is unaffected at 121C/250F. GC

      Reply
      1. Martha

        Yes I'm referring to a VG tincture I made but forgot to decarboxylare the material prior to mixing it with the VG so I will try this method. Thanks

        Reply
      2. jkwilborn

        The decarboxylation at 180F after it's been made seems a good choice over the oven method. I seem to think I need to know how long to maintain that temperature. Would you care to elaborate?

        Reply
        1. Skunk Pharm Research,LLC

          I would recommend hotter and faster. Here is the graph:https://skunkpharmresearch.com/decarboxylation/ Normally I would say watch the bubbles to tell exactly what is going on, but at 180F the activity is slow and less obvious. GW

          Reply
  18. mike

    If i Wanted to use Cannabis oil instead of flower as my material. Would you recommend emulsifying the cannabis oil in ethanol alcohol and then adding it to the vg to make it mix in well? What would be your best way of going about making it with decarbed cannabis oil? Thanks

    Reply
    1. Skunk Pharm Research,LLC

      Even mixing it with ethanol to facilitate mixing, some of the constituents will still precipitate out of solution, so the best way we've found to maximize cannabis essential oil suspension in VG, is to emulsify it. https://skunkpharmresearch.com/game-changer-emulsifying-vegetable-glycerin-and-bho-for-e-juice/ GW

      Reply
  19. emac757

    Defintely skip the EJmix or anything comparable. All garbage imo. Iv tried it all and using the one set of lungs we are given to test vaped plastic is not where its at. Flavrx makes a GSC cart that hits harder then anything Iv ever had. Its a terpene infused distillate that is highly effective after 1 low voltage (3.7) hit. Aside from that, dont waste countless grams of extract trying it at home unless you have an endless low cost supply.

    Reply
  20. emac757

    The internet can be a powerful tool for furthing ones knowledge prior to asking questions. QWET- Quick Wash EThanol SCFE- Sub Critical Fluid Extraction CO2 - Carbon Dioxcide GW- The one and only graywolf OG!!!

    Reply
        1. ganjagrynch

          Start with a pure extract in the form mentioned above and then add either an emulsifier like EjMix or get pure monoterpenes to reduce viscosity (make it thinner). EjMix does have something of a plastic taste especially if used at higher ratios than 1:1. Monoterpenes are expensive and will give your juice a citrus or pine flavor. There are products out there that use a mix of terpenes and claim to replicate well known strains. That's the only way I know to get truly potent ejuice from cannabis

          Reply
    1. Skunk Pharm Research,LLC

      SCFE could also be Super Critical Fluid Extraction. The world is probably isn't ready for another Tattered Old Graywolf, but GW could also be GW Pharmaceutical! LD-50 Rat means 50% of the rats died at that dosage and PEL means Permitted Exposure Limit. TLV is Threshold Limit Value and OW means Oh Wow, with OMG meaning Oh My Gawd! GW

      Reply
    1. Skunk Pharm Research,LLC

      It can be made a number of different ways, some more expensive than others. A denatured QWET is a less expensive way to make one from ground zero, and probably SCFE CO2 the other end of the scale, requiring more volume to achieve an attractive ROI. GW

      Reply
      1. Dale Robinson

        What do these abbreviations means? Sorry if it's a silly question just I'm still trying to get to grips with all this.

        Reply
  21. Dale Robinson

    I've bought the mighty fast herbal infuser, anyone know if it's any good I'm waiting for it to come and how to you make e liquid with it??

    Reply
    1. Skunk Pharm Research,LLC

      I predict you won't be happy with the results making e-juice. You can never approach the potency extracting with a non reducible solvent, that you mixing it with the solvent, because as the solvent becomes more saturated, it becomes less of a solvent and less able to dissolve more solute. GW GW

      Reply
      1. Dale Robinson

        Why wonthe I be happy with the results? Am I wasting my money buying this. I just want to be able to make the best possible e juice I can. What do you suggest??

        Reply
          1. Dale Robinson

            Hi again if I used the cold process to make my eliquid would it be best to decarb the weed before putting it inow the jar or decarb once I've made the juice? Can you help please.

            Reply
    2. Arfuitis

      Soaking 1-2 grams of finely chopped (but not too fine) potent decarboxilated weed with 10-15ml of glycerin, leaving it sit for 30 days, or heating it at 140 degrees centigrade for 2 hours every day for a fortnight should make some decent juice. It may take a few hits to get the desired effect. When I made it I let it sit for 30 days and heated it irregularly at between 70 - 120 degrees centigrade. The combination of the two seems to work really well but overheating it can be counterproductive. To increase potency increase the weed to glycerine ratio and amount. If you can afford it I'd suggest mixing 50ml of glycerin with 7-14 grams of quality nuggs. Mixing a mil or 2 of 100% alcohol may help with the extraction, i suggested 2 mil because ethanol produces more of a harsh vapor and I don't know how safe/unsafe vaping ethanol is. You could heat it up to have your e-juice made faster but the longer you wait, the better the flavor is awesome, and the effect was rather surprising. I don't understand the naysayers claiming glycerin is ineffective for vaping. I guess their objective is to get baked over just pleasantly buzzed. I suppose they were too impatient and didn't give the glycerin and cannabanoids time to coales

      Reply
      1. Skunk Pharm Research,LLC

        Some of the naysayers tolerance is high, because they are medical patients taking oral concentrates as well, and not noticing even a pleasant buzz. The fish trap exists only because of the fish and it is true that not everyone covets the same fish, so it is a individualized choice, dependent not only on tolerance, but as you note, based on the medical properties that you seek. GW

        Reply
      2. Mike

        Do you have a conversion ratio of trim to bud weights? I ve used a 2:1 trim to bud ratio from an old cooking oil recipe, and Im not sure if thats correct.it seems by adding more plant matter,but using the same amount of vg,it may not be enough vg.i wonder what the difference is in the amounts used,as in A)volume of material by weight and B) potency of bud compared to close trim. Thanks very much for your sharing and support of our incredible gift of our ladies.

        Reply
  22. emac757

    Cannabinoid distillate is really the only potent vape juice. I've had some luck with using a little bit of PEG to keep a winterized extract separated then adding 150° VG and whipping it with my CAT scientific emulsifier. But then you have adding liquid plastic to your mix which I don't trust, food grade or not. Terpene infused distillate is really the only pleasurable vape juice iv experienced thus far ie Flavrx GSC carts give great medication with 1 average hit with a great taste. Aside from that, I can't honestly say what's left as a viable method. Best of luck.

    Reply
  23. Alvin

    Did anyone manage to make potent ecig juice with VG? I don't mean mixing VG and already extracted oil. I mean using VG as solvent like the above? I followed the Ruffhouse video and did not get anything potent enough. Or is it my tolerance? I even changed it up and only used the oil from first 2 washes. Still nothing significant. Any advice? I do not wish to use the RSO method because it will separate and is very messy with mixed with VG. My main goal is a potent vape liquid. Can anyone help?

    Reply
    1. Skunk Pharm Research,LLC

      Not that I'm aware of. Even emulsifying VG and cannabis Absolute, we weren't able to achieve a 50/50 blend. GW

      Reply
      1. EstablishedPilot

        Wanted to post because I noticed you're relatively active in replying. I'm interested in making ejuice with VG and flower. What is the best approach? Making some kind of concentrate and then dissolving in VG, or do you recommend the RuffHouse video (which brought me here by the way) method? It seems like you are suggesting that trying to use VG as the solvent itself is not as viable. So would making something like a QWISO be effective?

        Reply
    2. Skunk Pharm Research,LLC

      Actually, I prefer to not use VG/PG/PEG as a carrier solvent, because it is something else the lungs have to expectorate, and our Pharm D brain trust has reservations about the long term effects. I also have never had a e-juice hit remotely comparing to a dab off a nail, so either use a skillet instead of a cart, or use a cart of decarboxylated Absolute or Clear. Locally, Clear cart producers are adding monoterpenes for aroma and flavor, which also serves as a solvent to make the concentrate flow. GW

      Reply
    3. andrew

      yes - using this it's easy as and supurb results - used vg/pg 50/50 mix from vape shop, 1 oz herbs, flavouring - https://magicalbutter.com/

      Reply
    4. Arfuitis

      Soaking 1-2 grams of finely chopped (but not too fine) potent decarboxilated weed with 10-15ml of 100% vegetable glycerin, leaving it sit for 30 days, or heating it at 140 degrees centigrade for 2 hours every day for a fortnight should make some decent juice. It may take a few hits to get the desired effect. When I made it I let it sit for 30 days and heated it irregularly at between 70 – 120 degrees centigrade. The combination of the two seems to work really well but overheating it can be counterproductive. To increase potency increase the weed to glycerine ratio and amount. If you can afford it I’d suggest mixing 50ml of glycerin with 7-14 grams of quality nuggs. Mixing a mil or 2 of 100% alcohol may help with the extraction, i suggested 2 mil because ethanol produces more of a harsh vapor and I don’t know how safe/unsafe vaping ethanol is. You could heat it up to have your e-juice made faster but the longer you wait, the better the flavor is awesome, and the effect was rather surprising. I don’t understand the naysayers claiming glycerin is ineffective for vaping. I guess their objective is to get baked over just pleasantly buzzed. I suppose they were too impatient and didn’t give the glycerin and cannabanoids time to coalesce

      Reply
  24. Dale Robinson

    Hi I'm looking to make my first ever batch of thc tincture 😆 can anyone help suggest what is the best method to start with? I'm new to all this and seen so much different information that's it's pickled my head haha 😂

    Reply
    1. Scott

      All this info would be amazing if it worked! I have tried this process 15 times.....Exactly following the directions. It simply does not work.

      Reply
  25. Benito Cgognito

    Hi =) Fantastic article so thank you. I came here via RuffHouse Studios youtube video, Cannabasics #29, which referenced your blog. My question is, if I intend to solely vaporize this VG tincture in an E-cig, is it necessary for me to decarboxylate the finished product (or the plant material prior) in order to activate the THC? Given that it is heated during vaping... Thanks in advance of your response. Benny

    Reply
    1. Skunk Pharm Research,LLC

      It's not necessary to decarboxylate, but you can't make a very potent e-juice solution extracting with VG, because you'll never get much higher than about 30%. E-juice is typically a mix of VG/PG/PEG and the concentrate is dissolved in it, instead of extracted with it. This article is oriented toward those taking glycerin extracts orally. GW

      Reply
  26. Craig Steffen

    This is the Information we needed to confirm what we learned thru research and experience in the processing of this marvelous plant.

    Reply
  27. clover

    Hello Skunk Pharm team, Firstly, this guide is extremely well-written with intricate, factual details. Spot on guys. I am very interested in using the Heat Extraction method. However, I can't seem to find the specific ratios of material to use in this guideline (nor the comments but I didn't look too hard, 410+ posts). So I went on a few websites to get some anectodal perspectives. So the following estimated numbers in this list may be wrong. Correct me if I'm wrong: - 1 Litre of Vegetable Glycerine - 1 Ounce of Medium-Quality Bud - 3 ml of Flavouring per 30 ml/Dropper Bottle .... Anything else I am missing? Other questions I had: 1. To add flavouring, do we require proof grain alcohol? And even if we choose to not add flavouring, the VG and dry material is all that is mixed? I re-read the guide many times so if I missed anything that would be embarrassing lol. 2. Can another alternative for heating be an electric heating table? (goo.gl/MGjaAe). I would think that the hot oil surrounding the jar of material and VG in the Crockpot would offer more points of thermal heating than the table. Pros for the table however, is that there would be no need for oil (saves $$) and it could fit more jars. But I'd rather do what is more successful, so what do you think? 3. To confirm the thermal cycling process: After 30 minutes of stirring at 180F (82C), we take the jar out, let it cool to room temperature (say, 5-10 mins), and repeat 5 more times? 4. To confirm the potency method: After the thermal cycling process and the first press has been completed, I put the material that was just pressed back in the jar, along with fresh glycerine and bud, and start cycling again? 6 times for thermal process again? This should cover it. Thank you so much and once again, great job on the post. Skunk Pharm has much of my respect. Take care.

    Reply
  28. JJ

    I read somewhere that if you are making a cannabis glycerite to vape, you will need to add water. The ratio of water to glycerin should be around 1 to 3. Should I add the water at the completion of making the glycerite or before starting when I am first adding the glycerine with the cannabis? Thank you.

    Reply
  29. Brian

    Hi, Great read. Do I still need to decarb the plant material if heated with the crockpot method?I've been vaping the glycerin in a little pen (the ones with the empty cartridges that you fill up) but is very weak. My ratios of plant material to VG is like you stated in the article. I would appreciate any help. Thanks again,

    Reply
    1. Skunk Pharm Research,LLC

      Extracting with VG produces a weak tincture. VG is also limited to what it will hold in solution, so the only way we found to get saturation close to 50% was using a Homogenizer. https://skunkpharmresearch.com/game-changer-emulsifying-vegetable-glycerin-and-bho-for-e-juice/ Another solution is to use PG or PG with the VG.

      Reply
      1. Bader

        Very interesting... So for example, if a 70% PG 30% VG mix was used, with the same extraction method, it will result in a more potent tincture for Vaping? What will the saturation % be in that case? Thank you for the grate info.

        Reply
        1. Skunk Pharm Research,LLC

          Even with solvents that can be mixed at any ratio with with the solute, there are limits to how much it will extract itself, before becoming saturated to the point that it stops. In Heaven, that point would be around 50%, and here on Earth something less. I haven't extracted with PG, so have no personal experience, but at best it will ostensibly be less than 50%. GW

          Reply
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