Game changer Emulsifying Vegetable Glycerin and BHO for E-Juice

Whoop, whoop, lu lu lu lu lu lu lu lu lu lu lu lu!!!!!!!!!1  Hee, hee, hee, snicker, snark, snort, don’t you just love it when a plan comes together?

Those of ya’ll who’ve tried to blend BHO and Vegetable Glycerin to make e-juice, know it doesn’t readily happen and you are limited in the potency levels that you can reach extracting with glycerin as the menstruum.

You are limited even adding a surfactant like lethicin, to promote absorption, so that market hasn’t taken off as readily as it might if it delivered a more potent hit.

At the suggestion of CAT Scientific, whom has supplied Skunk Pharm Research with equipment for testing, we tried their X-120 Homogenizer with a T-17 (N) generator shaft assembly, to see if they would not only blend, but stay blended.

For that experiment, we heated 250 ml of VG to 66C/150F in a 500 ml beaker, and added 6 grams of green BHO, which I’ve saved for several years as an example of too many washes using an open tube.  Before investing any amounts of prime oil, best to see what it does with bad example show and tell samples.

250 ml is about the minimum that can be processed with the T-17 (N)  generator in that sized beaker, as it is high precision and relies on the liquid as its lubricant.  CAT S, not only published that caveat in their supplied “destruction manual”, but passed it on to us in an e-mail to make sure we read the manual before firing up the homogenizer.

They also provide the caveat that homogenizers don’t like vortexes, for the same reason, so it can’t be used in the center of the container, only around the center.  That seemed fair enough, so we followed those simple instructions in the test.

Wowza!  It made about one minutes work of fully emulsifying the BHO and VG, producing an light green opaque solution, which hasn’t observably changed in 60 hours of standing, so we will be moving on to seeing just how much BHO we can mix with 250 ml of VG.

We will run it up to 50% BHO, in the next trial, but will start with a fresh sample so that we can field test it on patients afterwards.  At CAT’s suggestion, we will use a T-17 (V) generator shaft assembly, because the viscosity will be much higher.

I’ve also started dialog with an associate who is an e-juice manufacturer, whom has a market for the end product, so can test on a much larger scale.  We donate our meds, but over half a liter of e-juice would far exceed current demand, while demand for the same BHO in cancer meds continues to be strong.

You heard it here folks, this device is a game changer in the e-juice market!!!

While on the spendy side for ma and pa, they could produce more e-juice in about a minute, than they would likely need in a year anyway.  It is however, easily in the price range for small groups, and chump change for someone producing e-juice for the market place.  In fact, for those in the market, CAT makes much larger machines than the hand held unit that we are testing.

Contact information for this sweetheart is and bon appetite!

Here is a picture of the X-120, as well as the T-17 (N) generator, as well as the 250 ml emulsion that we created three days ago:

X-120 Homogenizer-1-1CAT MCS-66 stirring hotplate-1-1Homogenizer in action-1-1


UPDATE 4/16/14

By Joe

We had the opportunity to make a much larger batch of BHO/Glycerin e-juice. We started by winterizing around 270g of raw extract in a dry ice bath for one hour and subsequently filtering to 20 um. We then decarboxylated the extract at 250F until all the small CO2 bubbles were gone. The extract cooled to 150F before continuing. The final volume of extract was just under 250ml and we brought the total volume to 500ml with vegetable glycerin while stirring. It took only a few minutes to completely mix the solution and it stayed mixed for a few weeks. *With this large of a volume you must keep the stir bar on and keep turning the vessel while the homogenizer is running. *Place the head of the homogenizer below the surface but not completely below the interface of the two solutions.

After two weeks the solution started getting a little oily on the surface; which was quickly fixed by the addition of a little glycerin and re-homogenizing. The postulated reasoning for the separation is thus; we calculated the ratio with raw extract and allowed for a 20% loss due to winterizing and decarbing. The final volume of oil was estimated from a beaker, not a graduated cylinder, so the margin of error is greater than +/- 5% especially since the oil was between two graduations. The volume to volume ratio was close to 50/50 and was easily dropped into a wickless e-cig liquid tank.

The reviews coming back from patients are positive and some newer patients have even asked for a more dilute version! The flavor is pleasant as well!


 Answers to two most ask questions

The question, “How ya’ll do that”, keeps arising, so here are some more process details on Joe and my previous experiment blending 24 grams of BHO Absolute into 39 grams of VG.

We started with an ounce of borrowed, raw oleoresin BHO extract, which I redissolved into about 10X warm 190 proof ethanol, and stored in a 0F freezer for 48 hours, before filtering out the plant waxes and cooking off the alcohol in a 250F oil bath, and then decarboxylating the Absolute to about 70%.

Yield was 24 grams of carboxylic acid Absolute, which we decanted it into a 140 ml graduated beaker.

While the Absolute was decarboxylating, we heated up a 100 ml beaker of Kosher Vegetable Glycerin to 65C, using a CAT Scientific stirring hot plate, and set up the CAT Scientific 120 X variable speed drive motor, with T17 Homogenizer and “N” impeller on its stand.

After decanting the 24 grams of Absolute into the 140 ml beaker, we added 24 grams of 150F Vegetable glycerin and set the beaker on the homogenizer stand base and lowered the homogenizer shaft until there was just enough space left between the bottom of the beaker and the rotor, that when the beaker was held firmly against the base, as it was rotated and oscillated in small circles, there was no contact between the two.

That allowed us to process the minimum amount of material, and still keep the rotor fully submerged, in the 140 ml beaker, which was about three rotor diameters wide. Pressing the beaker against the stand base and adjusting rotor speed to about two thirds throttle, Joe moved the beaker in an oscillating motion, working around the bottom, where there was an inhomogeneous mixture.

Once we had reach the process limits, we started slowly adding VG and continuing to oscillate and rotate the beaker, until the oil and VG were fully homogenized. At that point, we had added a total of 39 grams of VG to 24 grams of BHO Absolute.

As we added glycerin, we raised the homogenizer some, so as to keep the rotor just under the surface of the area that we were working. We kept the rotor submerged to keep it lubricated and away from the center of the beaker to avoid generating a vortex.

The second question is, “How long was it stable”, and I note that the first post was 12-6-2013, and the first emulsion has started developing a fine dark hairline around the top of the test tube, so 90 days or so.

The second emulsion was returned to the person loaning us the oil and sat around unchanged for about a week while he shared it with volunteers using an Essential VAAAPP pen. It produced impressive volumes of vapor, produced good medicinal effects, and was rated as couch locking in excess.

It also separated in the VAAAPP pen bottle after heating, but in that application still delivered a potent hit.

After a week, there was no separation ring in the original container, but he stuck it in the freezer to preserve it, which caused the VG and Absolute to separate.

The short answer to the stability question, is that it does eventually separate all on its own at ambient temperatures and you can speed it up with heat or cold. In the middle lies opportunity, which as you note, Joe has already started exploiting with clients on larger scales!




144 responses to this post.

  1. Tween 80 (Polysorbate 80, HLB=15) stabilizes oil-in-glycerin emulsions. You need a high HLB surfactant to do this, that’s why lecithin does not work (HLB=4). Has anyone tried to do this with BHO in glycerin?


  2. Posted by Danette on October 29, 2015 at 8:36 AM



  3. here’s the deal…

    I first got ej from amazon, hated the taste. then bought puff because they had flavors. then switched to Vapeur because they had “flavorless” (10x better than ejmix no taste) they also had flavors which i tried out which were better than puff. I would completely recommend vapeur, customer service is amazing… btw… i forgot to mention the price point is perfect. 30ml for 16.99. come on, you can’t beat that price, more money in my pocket.


    • Posted by Captain Trips on October 14, 2015 at 4:27 PM

      O.k. but does it kick like a mule when you hit it?


      • Definitely, It not only kicks but you actually get some VAPOR! you can see what your doing lol! it’s awesome, i’m planning on starting up cartridge business now, they sell the gallon size which makes up to 3900 grams which you cut and can make a wopping 70k profit… thats amazing my homies that are trying it out say its the best they have tried. All i can do is spread the word :)


  4. Got my EJ Mix from


  5. could you use a Dremel for a drive unit to keep the cost down?


  6. Posted by BushRoot on September 12, 2015 at 9:34 PM

    “4 Corners Cannabis” uses 50% PEG 400 and 50% VG.


  7. Posted by Jim mcintire on July 22, 2015 at 6:19 PM

    My emulsion (solution?) remained stable. I did not add Simpson oil to ethanol… I added decarboxylated herb to ethanol and steeped for about a week. The steep was then added to a 50/50 vg/pg solution in equal parts and then evaporated to 1/2 starting volume (all EtOH and h2o should be gone). The result is an ugly greenish brown liquid that readily vapes and seems to be stable. Very low med content though…still works ok as a night night.


  8. Posted by Quinn on July 22, 2015 at 1:14 PM

    Lazy chemistry that will undoubtedly clog and ruin atomizers. It will also provide an unequal distribution of product throughout, thereby making dosage unpredictable. It doesn’t meet a single qualification I look for before a prototype hits the sales floor.


  9. Posted by Global on July 1, 2015 at 8:57 AM

    Any feed back on Puff Majic for Majic Vapor LLC as opposed to Ejmix or PG, Peg, VG ect…….


  10. Posted by jim on May 16, 2015 at 7:29 AM

    Wouldnt ethanol extract work just as well without the solubility problems? Mix the EtOH extract with the VG/PG and then heat off the EtOH?


    • Posted by dR3 on June 1, 2015 at 10:24 AM

      I imagine a combo of alcohol and (VG +/or PG) would extract reasonably well, but upon boiling off the alcohol the *goodies* would likely not be well-soluble and then need to be emulsified, via mechanical agitation or pressure or ________ ???

      Would love to hear the Pharm’s perspective on this =) !!


      • Posted by jim on June 1, 2015 at 10:46 AM

        I went ahead and tried this a couple weeks ago and it formed an emulsion straight off…no mechanical mixing needed. The active is a little weak but the emulsion has been very stable. I plan to try a double extraction next time (1x vol of EtOH used to soak 2 volumes of plant material).


    • Posted by Quinn on June 11, 2015 at 9:23 AM

      I did a vg + ethanol + oil mixture last night. Upon evaporating the ethanol, the oil (a simpson oil extracted in 99% iso) separated and floated to the top. So… nope!
      5ml simpson oil : 120 ml v.g. : 60 ml 190 proof grain alcohol.
      24 min @ 250 f, reduced to 150 for 6 hours until alcohol vapor and taste is no longer present.

      While my “solvent assisted hemoginization” did not work to super-saturate the v.g., I syphoned off the glycerin from under the oil layer and loaded it up into my joyetech. definitely kicked.

      I really respect you guys at skunk pharm and use your data every day. Thanks for your brilliant and diligent work! However, I don’t believe intentionally providing consumers with a non-shelf-stable product is right, and the cost of a hemoginizer is not worth the trouble of building a tincture that will break 100% of the time imo.

      It’s not salad dressing, you can’t just shake it up lol.


      • Posted by Whycome on July 22, 2015 at 12:58 PM

        Of course you can just shake it up. While that won’t provide long-term emulsification, much like a salad dressing it can be shaken vigorously immediately before use.
        My first lazy attempt at vaping was just squeezing some store-bought cold ethanol extract bho [hooray for living in a state where you can store-buy bho! :-)] into a tank-style vape cartridge with a bit of 50/50 PG/VG flavor juice. It doesn’t stay mixed, but it works. Hand warming, and vigorous shaking before a hit are not that much of a pain…


        • Posted by Quinn on July 22, 2015 at 1:20 PM

          Lazy chemistry that will clog and break atomizers. Also, it produces an unpredictable dosage throughout as the second you stop emulsifying, the oil begins rebonding. Doesn’t pass a single test I would put it through before hitting the sales floor.


  11. Posted by skyler on April 1, 2015 at 1:24 PM

    Would this work with PG?


  12. Posted by rhu austin on March 23, 2015 at 11:15 AM

    Im courious ,can i use the hot glycerine extraction Method using vg snd poly glycerine mix to make vape pen oil.. .they use both to make vape pen liquid for tobacco…im not real technical so can you keep it simple plz do i need to decarboxulate it first .thank you for any info you can help me with .


  13. Posted by fire on March 21, 2015 at 12:38 AM

    Has anyone tried blasting directly onto glycol or glycerin? Wouldn’t the butane dissolve the glycol and distribute it into the bho. This also might make it more viscous which should help in the putting process.


    • Posted by fire on March 21, 2015 at 12:44 AM

      I meant to say the added viscosity of the glycol would allow for an extremely low temp purging process.


      • Posted by fire on March 21, 2015 at 1:21 AM

        Actually it would prbly just freeze and stay separate. Still it might homogenize during the purging process after the glycol melts.


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